Golsteyn, Roy
Professor
Biological Sciences Department
- Phone
- (403) 332-4553
- roy.golsteyn@uleth.ca
Lab
- Phone
- (403) 332-4418
About Me
Courses
Biol 3110 Cell Signalling
Biol 4180 Natural Products in Biology
Biol 3110 Cell Signalling
Biol 4180 Natural Products in Biology
Biography
PhD Biochemistry University of Cambridge
Cancer Drug Discovery
Servier Pharmaceutical Company, Paris, France
Cancer Drug Discovery
Servier Pharmaceutical Company, Paris, France
Current Research
| Title |
Location |
Principal Investigator | Co-Researchers | Grant Agency |
Grant Amount |
Grant Time Period |
|---|---|---|---|---|---|---|
| Investigation of cell division using new natural products | Lethbridge, AB | Roy Golsteyn | ||||
| Investigation of cell division using new natural products | Lethbridge, AB | Roy Golsteyn | NSERC | |||
| Natural products: Infrastructure | Lethbridge, AB | Roy Golsteyn | ||||
| Natural products: Infrastructure | Lethbridge, AB | Roy Golsteyn | Canada Foundation for Innovation | |||
| Prairie to Pharmacy Program | Lethbridge, AB | Roy Golsteyn | ||||
| Prairie to Pharmacy Program | Lethbridge, AB | Roy Golsteyn | Power Corp. Canada |
Publications
1. Bosco, A; Molina, L; Kernéis, SM; Hatzopoulos, G; Favez, T; Gönczy, P; Tantapakul, C; Maneerat, W; Yeremy, B; Williams, DE; Andersen, RJ; Golsteyn, RM. (2021). Pulchelloid A, a sesquiterpene lactone from the Canadian prairie plant Gaillardia aristata inhibits mitosis in human cells. Molecular Biology Reports, 48, 5459-5471.
2. Jan M. Tuescher , Chad R. Beck, Locke Spencer, Benjamin Yeremy, Yutong Shi, Raymond J. Andersen and R.M. Golsteyn. Extracts prepared from a Canadian toxic plant induce light-dependent peri-nuclear vacuoles in human cells. Toxins. 13. e138. 2021
3. Tuescher, J. D Tailfeathers, SM Kernéis, B Baratte, S Ruchaud, S Bach. R.M. Golsteyn The Canadian prairie plant Thermopsis rhombifolia contains luteolin, a flavone that inhibits cyclin dependent kinase 9 and arrest cells in the G1-Phase of the cell cycle. Journal of Natural Health Product Research 2: 1-14. 2020.
4. Molina, L; Williams, DE; Andersen, RJ; Golsteyn, RM. (2021). Isolation of a natural product with anti-mitotic activity from a toxic Canadian prairie plant. Heliyon, 7, e07131.
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5. Swift, L.H. and R.M. Golsteyn. Experimental determination of checkpoint adaptation by mitotic shake-off and microscopy. Methods in Molecular Biology. 1769:159-168 doi: 10.1007/978-1-4939-7780-2_10. 2018.
6.tKalsbeek, D. and R.M. Golsteyn. "Checkpoint adaptation and micronuclei formation as mechanisms that contribute to genomic instability in human cells." International Journal of Molecular Sciences.18. 2344; doi:10.3390/ijms18112344 2017.
7.tBosco, A. and R.M. Golsteyn. Emerging anti-mitotic activities and other bio-activities of sesquiterpene compounds upon human cells. Molecules. 22:459-480. 2017. doi:10.3390/molecules22030459
8.tLewis, C.W. and R.M. Golsteyn. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. 15:3131-3145. 2016.
9.tSwift, L.H. and R.M. Golsteyn. Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration dependent manner in cancer cells. Biology of the Cell. 108:127-148. 2016.
2. Jan M. Tuescher , Chad R. Beck, Locke Spencer, Benjamin Yeremy, Yutong Shi, Raymond J. Andersen and R.M. Golsteyn. Extracts prepared from a Canadian toxic plant induce light-dependent peri-nuclear vacuoles in human cells. Toxins. 13. e138. 2021
3. Tuescher, J. D Tailfeathers, SM Kernéis, B Baratte, S Ruchaud, S Bach. R.M. Golsteyn The Canadian prairie plant Thermopsis rhombifolia contains luteolin, a flavone that inhibits cyclin dependent kinase 9 and arrest cells in the G1-Phase of the cell cycle. Journal of Natural Health Product Research 2: 1-14. 2020.
4. Molina, L; Williams, DE; Andersen, RJ; Golsteyn, RM. (2021). Isolation of a natural product with anti-mitotic activity from a toxic Canadian prairie plant. Heliyon, 7, e07131.
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5. Swift, L.H. and R.M. Golsteyn. Experimental determination of checkpoint adaptation by mitotic shake-off and microscopy. Methods in Molecular Biology. 1769:159-168 doi: 10.1007/978-1-4939-7780-2_10. 2018.
6.tKalsbeek, D. and R.M. Golsteyn. "Checkpoint adaptation and micronuclei formation as mechanisms that contribute to genomic instability in human cells." International Journal of Molecular Sciences.18. 2344; doi:10.3390/ijms18112344 2017.
7.tBosco, A. and R.M. Golsteyn. Emerging anti-mitotic activities and other bio-activities of sesquiterpene compounds upon human cells. Molecules. 22:459-480. 2017. doi:10.3390/molecules22030459
8.tLewis, C.W. and R.M. Golsteyn. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. 15:3131-3145. 2016.
9.tSwift, L.H. and R.M. Golsteyn. Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration dependent manner in cancer cells. Biology of the Cell. 108:127-148. 2016.
Degrees
Ph.D. (Biochemistry), University of Cambridge
MSc, Medical Biochemistry, University of Calgary
BSc, Biological Sciences, University of Lethbridge
MSc, Medical Biochemistry, University of Calgary
BSc, Biological Sciences, University of Lethbridge
Research Interests
The Prairie to Pharmacy Program
We discover and use natural products from Canadian plants. Our research takes us into:
Natural products in biology and medicine
Natural product chemistry
Imaging technology including drones
Traditional knowledge and recognition of local First Nation communities
Interested students and recent PhD graduates are invited to apply for research positions.
We discover and use natural products from Canadian plants. Our research takes us into:
Natural products in biology and medicine
Natural product chemistry
Imaging technology including drones
Traditional knowledge and recognition of local First Nation communities
Interested students and recent PhD graduates are invited to apply for research positions.
In The Media
tMedia - Name - Title - Date
1. Evening news. Global, CTV. (2020, January 10). Interviews highlighting the Power Corporation and Canada Life Donation to UoL and Prairie to Pharmacy Program. Evening news. Global, CTV.
2.tAboriginal People Television Network -APTN (2019, November 29). Prairie to Pharmacy Program and collaboration with First Nation communities. Evening news. Aboriginal People Television Network.
3.tThe Lethbridge Herald (newspaper). "U of L names Alumni Honour Society Inductees." 30 August 2019.
4.tWestern Producer (newpaper). "Native plants could provide new antibiotics." 6 June 2019.
5.tThe Lethbridge Herald (newspaper). "Funding to Benefit University." 19 September 2017.
6.tThe Lethbridge Herald (newspaper). "U of L Researcher studying prairie plants for medicinal purposes." 6 September 2017.
7.tCBC Calgary Eye-opener Radio Interview (CBC Radio 1) "Notes from the field: Wild flowers and cancer research." 19 June 2017.
1. Evening news. Global, CTV. (2020, January 10). Interviews highlighting the Power Corporation and Canada Life Donation to UoL and Prairie to Pharmacy Program. Evening news. Global, CTV.
2.tAboriginal People Television Network -APTN (2019, November 29). Prairie to Pharmacy Program and collaboration with First Nation communities. Evening news. Aboriginal People Television Network.
3.tThe Lethbridge Herald (newspaper). "U of L names Alumni Honour Society Inductees." 30 August 2019.
4.tWestern Producer (newpaper). "Native plants could provide new antibiotics." 6 June 2019.
5.tThe Lethbridge Herald (newspaper). "Funding to Benefit University." 19 September 2017.
6.tThe Lethbridge Herald (newspaper). "U of L Researcher studying prairie plants for medicinal purposes." 6 September 2017.
7.tCBC Calgary Eye-opener Radio Interview (CBC Radio 1) "Notes from the field: Wild flowers and cancer research." 19 June 2017.
Research Areas
Natural products
Ethnobotany
Prairie to Pharmacy Program
Previous Research Areas
Cancer research
Drug discovery
Drug discovery
Expertise
Pharmaceutical industry
Cancer Research
Natural products
Cell biology
Languages
French