Kovalchuk, Igor
Co-Chair/Professor
Biological Sciences Department
- Phone
- (403) 329-2579
- Fax
- (403) 329-2082
- igor.kovalchuk@uleth.ca
Coordinator/Professor
- Phone
- (403) 329-2579
- Fax
- (403) 329-2082
Lab
- Phone
- (403) 332-4418
Office Hours
Day (i.e. Monday, or MWF) By appointment only: 9:00 AM to 4:30 PM
About Me
I am a principal investigator in the "Plant biotechnology and epigenetics" laboratory.
Our lab has three research directions:
1. Genetic and epigenetic regulation of plant response to stress. We are using Arabidopsis thaliana (primarily) as a model.
2. Development of new varieties of hemp/cannabis and analysis of their medicinal properties using cell, tissue culture and animal models.
3. Analysis of medicinal effects of magic mushrooms and psilocybin.
We are particularly interested in transgenerational effects of stress and microevolution of plant stress tolerance/resistance.
In the past 10 years, I have been actively studying the medicinal plants, poppy and cannabis. In the lab, we have developed several novel varieties of cannabis and demonstrated their medicinal properties.
Our recent focus is on the development of in vitro and in vivo models of inflammation, aging, diabetes and other diseases and testing various medicinal plants and fungi.
Our lab has three research directions:
1. Genetic and epigenetic regulation of plant response to stress. We are using Arabidopsis thaliana (primarily) as a model.
2. Development of new varieties of hemp/cannabis and analysis of their medicinal properties using cell, tissue culture and animal models.
3. Analysis of medicinal effects of magic mushrooms and psilocybin.
We are particularly interested in transgenerational effects of stress and microevolution of plant stress tolerance/resistance.
In the past 10 years, I have been actively studying the medicinal plants, poppy and cannabis. In the lab, we have developed several novel varieties of cannabis and demonstrated their medicinal properties.
Our recent focus is on the development of in vitro and in vivo models of inflammation, aging, diabetes and other diseases and testing various medicinal plants and fungi.
Biography
DEGREES:
07.1993 - physician diploma, Ivano-Frankivsk State Medical Academy, Ivano-Frankivsk, Ukraine
07.1996 - MD, Ivano-Frankivsk State Medical Academy, Ivano-Frankivsk, Ukraine
05.1998 - PhD (Genetics), Ukrainian Centre of Genetics, Kiev, Ukraine
11.2000 - MBA, (Management of International Scientific Projects), Ivano-Frankivsk Oil and Gas University
07.1993 - physician diploma, Ivano-Frankivsk State Medical Academy, Ivano-Frankivsk, Ukraine
07.1996 - MD, Ivano-Frankivsk State Medical Academy, Ivano-Frankivsk, Ukraine
05.1998 - PhD (Genetics), Ukrainian Centre of Genetics, Kiev, Ukraine
11.2000 - MBA, (Management of International Scientific Projects), Ivano-Frankivsk Oil and Gas University
Publications
2023
1.tLopos, LC, Panthi, U, Kovalchuk, I and Andriy Bilichak. (2023) MicroRNAs as Novel Tools for the Wheat (Triticum aestivum L.) Improvement of Wheat (Triticum aestivum L.). Current Genomics, in revision, IF: 2.69
2.tGhasemi Gojani, E, Wang, B, Li, D-P, Kovalchuk, O, Kovalchuk, I. (2023) Psilocybin Mitigates Inflammation in THP-1 Macrophages Exposed to Lipopolysaccharide and Enhances Viability while Reducing De-differentiation of High Glucose-High Lipid-Challenged β-Cells. Cells, in revision. IF: 7.67
3.tGhasemi Gojani, E, Wang, B, Li, D-P, Kovalchuk, O, Kovalchuk, I. (2023) Effect of THC, CBD, THCV, CBC and CBN cannabinoids on β-cells exposed to high glucose - high lipids. Cells, submitted. IF: 7.67
4.tKovalchuk, I. (2023) Role of epigenetic factors in response to stress and establishment of somatic memory of stress exposure in plants. Plants, in revision. IF: 4.66
5.tKovalchuk, I. (2023) Heritable responses to stress in plants. Quantitative Plant Biology, in press. IF:
6.tCherkasova, V, Ilnytskyy, Y, Kovalchuk, O, Kovalchuk, I. (2023) Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells. Int. J. Mol. Sci., in press. IF: 6.2
7.tGhasemi Gojani, E, Wang, B, Li, D-P, Kovalchuk, O, Kovalchuk, I. (2023) Anti-inflammatory effects of minor cannabinoids CBC, THCV, and CBN in human macrophages. Molecules, 28 (18), 6487. IF: 4.9
8.tRobinson, GI, Li, D, Wang, B, Rahman, T, Gerasymchuk, M, Hudson, D, Kovalchuk, O, Kovalchuk, I. Anti-Inflammatory Effects of Serotonin Receptor and Transient Receptor Potential Channel Ligands in Human Small Intestinal Epithelial Cells. Curr Iss Mol Biol, in press. IF: 3.1
9.tGerasymchuk, M, Robinson, GI, Vardinska, N, Ayedun, SA, Alozie, SC, Kovalchuk, O, Kovalchuk, I. (2023) Sex-dependent skin aging and rejuvenation strategies. Dermato, 3(3), 196-223.
10.tZaiachuk, M, Suryavanshi, SV, Pryimak, N, Kovalchuk, I, Kovalchuk, O. (2023) The anti-inflammatory effects of Cannabis Sativa extracts on LPS-induced cytokines release in immune and non-immune cells in vitro. Molecules, 28 (13), 4991. IF: 4.9
11.tFarahmand, H., Robinson, G., Gerasymchuk, M., Kovalchuk, I. (2023) Copper Sulphate Inhibits Penicillium olsonii Growth and Sporulation on Cannabis sativa. J Plant Pathology, 1-6. IF: 2.6
12.tBorisov, N., Ilnytskyy, Y., Byeon, B. Kovalchuk, O. Kovalchuk, I. (2023) Application of Drug Efficiency Index metric for analysis of post-traumatic stress disorder and treatment resistant depression gene expression profiles. Psychoactives, 2(2), 92-112.
13.tIlnytskyy, Y, Kovalchuk, I, Kovalchuk, O, Bibb, G. (2023) Genome-wide detection of chimeric transcripts in early-stage non-small cell lung cancer. Cancer Genomics Proteomics, in press. IF: 4.1
14.tZanikov, T, Gerasymchuk, M, Ghasemi Gojani, E, Robinson, G, Asghari, S, Groves, A, Haselhorst, L, Nandakumar, S, Stahl, C, Cameron, M, Li, D-P, Rodriguez-Juarez, R, Snelling, A, Hudson, D, Fiselier, A, Kovalchuk, O, Kovalchuk, I. (2023) The effect of combined treatment of psilocybin and eugenol on lipopolysaccharide-induced brain inflammation in mice. Molecules, 28(6), 2624. IF: 4.9
15.tTouahri, Y, …., Ilnytskyy, Y.,… Kovalchuk, I…., Schuurmans, CJ. (2022) Pten regulates endocytic trafficking of cell adhesion and signaling molecules to pattern the retina. Cell Reports, in press. IF:10.0
16.tZhong, N, Li, D-P, Wang, B, Kovalchuk, O, Kovalchuk, I. (2023) Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer. BAB, 48, 102627. IF: 4.0
17.tWang, B, Li, D-P, Fiselier, A, Kovalchuk, I, Kovalchuk, O. (2023) High-CBD/low-THC cannabis extracts inhibit COVID-19-associated proinflammatory factors via miRNA-mediated silencing in human small intestinal epithelial cell. Heliyon, 9, 8. IF: 3.78
2022
18.tGerasymchuk, M., Robinson, G., Groves, A., Haselhorst, L., Nandakumar, S., Kovalchuk, O., Kovalchuk, I. (2022) Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts. Cells, 11(23):3939. IF: 7.67
19.tCherkasova, V., Wang, B., Gerasymchuk, M., Fiselier, A., Kovalchuk, O., Kovalchuk, I. (2022) Use of Cannabis and Cannabinoids for Treatment of Cancer. Cancers, 11(9), 1391. IF: 7.4
20.tFiselier A, Byeon, B, Ilnytskyy, Y, Kovalchuk, O, Kovalchuk, I. (2022) Scatter Irradiation of Rat Brain Triggers Sex- and Brain Region-Specific Changes in the Expression of Non-Coding RNA Fragments. Epigenomes, 6(4), 35. IF: 2.5
21.tGerasymchuk, M.; Robinson, G.; Kovalchuk, O.; Kovalchuk, I. (2022) The Effects of Natural Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Secretory Phenotype in Human Dermal Fibroblasts. Int. J. Mol. Sci., 23 (15), 8804. IF: 6.2
22.tGhasemi-Gojani, E., Kovalchuk, O., Kovalchuk, I. (2022) Cannabis as a treatment for diabetes mellitus and its complications. Trends Endocrin Metabolism, 33(12), 828-849. IF: 12.0
23.tGerasymchuk, M.; Robinson, G.; Kovalchuk, O.; Kovalchuk, I. (2022) Modeling of the Senescence-Associated Phenotype in Human Skin Fibroblasts. Int. J. Mol. Sci., 23 (13), 7124. IF: 6.2
24.tSuryavanshi, SV, Zaiachuk, M, Pryimak, N, Kovalchuk, I, Kovalchuk, O. (2022) Cannabinoids alleviate the LPS-induced cytokine storm via attenuating NLRP3 inflammasome signaling and TYK2-mediated STAT3 signaling pathways in vitro. Cells, 11(9),1391. IF: 7.67
25.tFiselier A, Byeon, B, Ilnytskyy, Y, Kovalchuk, O, Kovalchuk, I. (2022) Sex-specific expression of non-coding RNA fragments in frontal cortex, hippocampus and cerebellum of rat. Epigenomes, 6(2), 11. IF: 2.5
26.tWang, B., Li, D-P, Cherkasova, V., Gerasymchuk, M., Narendran, A., Kovalchuk, I., Kovalchuk, O. (2022) Cannabinol inhibits cellular proliferation, invasion, and angiogenesis of neuroblastoma via novel miR-34a/tiMetF31/PFKFB3 axis. Cancers, 11(9), 1391. IF: 7.4
27.tKovalchuk, O., Wang, B, Li, D-P, Ilnystkyy, Y. and Kovalchuk, I. (2022) A miR-34a-guided, tRNAiMet-derived, piR_019752-like fragment (tRiMetF31) suppresses migration and angiogenesis of breast cancer cells via targeting PFKFB3. Cell Death Discovery, 8(1), 1-13. IF: 7.1
28.tKovalchuk, O., Wang, B, Li, D-P, Fiselier, A and Kovalchuk, I. (2022) New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts. Cell Death Discovery, 8(1), 1-12. IF: 7.1
29.tYadav NS, TItov, V, Ayemere, I, Byeon, B, Ilnytskyy, Y, Kovalchuk, I. (2022) Multigenerational exposure to heat stress induces phenotypic resilience, and genetic and epigenetic variations in Arabidopsis thaliana offspring. Front. Plant. Sci. 13:728167. IF: 5.75
30.tMalach, M. Kovalchuk, I. Kovalchuk, O. (2022) Medical Cannabis in Pediatric Oncology: Friend or Foe? Pharmaceuticals, 15(3), 359. IF: 5.9
2021
31.tCherkasova, V, Kovalchuk, O, Kovalchuk, I. Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer. Cancers, 13 (17), 4353. IF: 7.4
32.tZajachuk, M., Pryimak, N., Kovalchuk O., Kovalchuk, I. (2021) Cannabinoids, medical cannabis and tissue fibrosis: mechanisms and therapeutic potential. Fron. Med., 8, 713153. IF: 5.1
33.tPryimak, N. Zajachuk, M., Kovalchuk O., Kovalchuk, I. (2021) Cannabinoids, medical cannabis and tissue fibrosis: mechanisms and therapeutic potential. Fron. Cell Dev. Biol., 9, 715380. IF: 6.1
34.tBeacon, TH, Delcuve, GP, López, C, Nardocci, G, Kovalchuk, I, van Wijnen, AJ, Davie, JR. The dynamic broad epigenetic domain as a mark of essential genes. Clin. Epigen., 13 (1), 1-17, IF: 7.3.
35.tSisu, …., Kovalchuk, I…., Schuurmans, CJ. Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding. Neuron, 109 (18), 2847-2863. e11. IF: 14.4
36.tGogolev YV, … Kovalchuk I, …Yadav, NS, Viktor Korzun. OMICs, Epigenetics and Genome Editing Techniques for Food and Nutritional Security. Plants, in press. IF: 4.66
37.tSorokin, A., Yadav, N., Gaudet, D., Kovalchuk, I. (2021) Development and standardization of rapid and efficient seed germination protocol for Cannabis sativa. Bio-Protocols, 11 (1), e3875-e3875. IF: 1.0
38.tBorisov, N., Ilnytskyy, Y., Byeon, B. Kovalchuk, O. Kovalchuk, I. (2021) System, method and software for calculation of cannabis drug efficiency index in the reduction of inflammation. Int. J. Mol. Sci., 22 (1), 388. IF: 6.2
39.tBressler, K.R., Ross, J.A., Ilnytskyy, S., Vanden Dungen, K., Taylor, K., Patel, K., Zovoilis, A., Kovalchuk, I. and Nehal Thakor. (2021) Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal Kinase (JNK). Cell Stress Chaperones, 26 (1), 253-264. IF: 2.6
40.tKovalchuk, A., Wang, B., Li, D-P., Rodriguez-Juarez, R., Ilnytskyy, Y., Kovalchuk, I., Kovalchuk, O. (2021) Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19? Aging, 13, 1571-1587. IF: 5.95
1.tLopos, LC, Panthi, U, Kovalchuk, I and Andriy Bilichak. (2023) MicroRNAs as Novel Tools for the Wheat (Triticum aestivum L.) Improvement of Wheat (Triticum aestivum L.). Current Genomics, in revision, IF: 2.69
2.tGhasemi Gojani, E, Wang, B, Li, D-P, Kovalchuk, O, Kovalchuk, I. (2023) Psilocybin Mitigates Inflammation in THP-1 Macrophages Exposed to Lipopolysaccharide and Enhances Viability while Reducing De-differentiation of High Glucose-High Lipid-Challenged β-Cells. Cells, in revision. IF: 7.67
3.tGhasemi Gojani, E, Wang, B, Li, D-P, Kovalchuk, O, Kovalchuk, I. (2023) Effect of THC, CBD, THCV, CBC and CBN cannabinoids on β-cells exposed to high glucose - high lipids. Cells, submitted. IF: 7.67
4.tKovalchuk, I. (2023) Role of epigenetic factors in response to stress and establishment of somatic memory of stress exposure in plants. Plants, in revision. IF: 4.66
5.tKovalchuk, I. (2023) Heritable responses to stress in plants. Quantitative Plant Biology, in press. IF:
6.tCherkasova, V, Ilnytskyy, Y, Kovalchuk, O, Kovalchuk, I. (2023) Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells. Int. J. Mol. Sci., in press. IF: 6.2
7.tGhasemi Gojani, E, Wang, B, Li, D-P, Kovalchuk, O, Kovalchuk, I. (2023) Anti-inflammatory effects of minor cannabinoids CBC, THCV, and CBN in human macrophages. Molecules, 28 (18), 6487. IF: 4.9
8.tRobinson, GI, Li, D, Wang, B, Rahman, T, Gerasymchuk, M, Hudson, D, Kovalchuk, O, Kovalchuk, I. Anti-Inflammatory Effects of Serotonin Receptor and Transient Receptor Potential Channel Ligands in Human Small Intestinal Epithelial Cells. Curr Iss Mol Biol, in press. IF: 3.1
9.tGerasymchuk, M, Robinson, GI, Vardinska, N, Ayedun, SA, Alozie, SC, Kovalchuk, O, Kovalchuk, I. (2023) Sex-dependent skin aging and rejuvenation strategies. Dermato, 3(3), 196-223.
10.tZaiachuk, M, Suryavanshi, SV, Pryimak, N, Kovalchuk, I, Kovalchuk, O. (2023) The anti-inflammatory effects of Cannabis Sativa extracts on LPS-induced cytokines release in immune and non-immune cells in vitro. Molecules, 28 (13), 4991. IF: 4.9
11.tFarahmand, H., Robinson, G., Gerasymchuk, M., Kovalchuk, I. (2023) Copper Sulphate Inhibits Penicillium olsonii Growth and Sporulation on Cannabis sativa. J Plant Pathology, 1-6. IF: 2.6
12.tBorisov, N., Ilnytskyy, Y., Byeon, B. Kovalchuk, O. Kovalchuk, I. (2023) Application of Drug Efficiency Index metric for analysis of post-traumatic stress disorder and treatment resistant depression gene expression profiles. Psychoactives, 2(2), 92-112.
13.tIlnytskyy, Y, Kovalchuk, I, Kovalchuk, O, Bibb, G. (2023) Genome-wide detection of chimeric transcripts in early-stage non-small cell lung cancer. Cancer Genomics Proteomics, in press. IF: 4.1
14.tZanikov, T, Gerasymchuk, M, Ghasemi Gojani, E, Robinson, G, Asghari, S, Groves, A, Haselhorst, L, Nandakumar, S, Stahl, C, Cameron, M, Li, D-P, Rodriguez-Juarez, R, Snelling, A, Hudson, D, Fiselier, A, Kovalchuk, O, Kovalchuk, I. (2023) The effect of combined treatment of psilocybin and eugenol on lipopolysaccharide-induced brain inflammation in mice. Molecules, 28(6), 2624. IF: 4.9
15.tTouahri, Y, …., Ilnytskyy, Y.,… Kovalchuk, I…., Schuurmans, CJ. (2022) Pten regulates endocytic trafficking of cell adhesion and signaling molecules to pattern the retina. Cell Reports, in press. IF:10.0
16.tZhong, N, Li, D-P, Wang, B, Kovalchuk, O, Kovalchuk, I. (2023) Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer. BAB, 48, 102627. IF: 4.0
17.tWang, B, Li, D-P, Fiselier, A, Kovalchuk, I, Kovalchuk, O. (2023) High-CBD/low-THC cannabis extracts inhibit COVID-19-associated proinflammatory factors via miRNA-mediated silencing in human small intestinal epithelial cell. Heliyon, 9, 8. IF: 3.78
2022
18.tGerasymchuk, M., Robinson, G., Groves, A., Haselhorst, L., Nandakumar, S., Kovalchuk, O., Kovalchuk, I. (2022) Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts. Cells, 11(23):3939. IF: 7.67
19.tCherkasova, V., Wang, B., Gerasymchuk, M., Fiselier, A., Kovalchuk, O., Kovalchuk, I. (2022) Use of Cannabis and Cannabinoids for Treatment of Cancer. Cancers, 11(9), 1391. IF: 7.4
20.tFiselier A, Byeon, B, Ilnytskyy, Y, Kovalchuk, O, Kovalchuk, I. (2022) Scatter Irradiation of Rat Brain Triggers Sex- and Brain Region-Specific Changes in the Expression of Non-Coding RNA Fragments. Epigenomes, 6(4), 35. IF: 2.5
21.tGerasymchuk, M.; Robinson, G.; Kovalchuk, O.; Kovalchuk, I. (2022) The Effects of Natural Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Secretory Phenotype in Human Dermal Fibroblasts. Int. J. Mol. Sci., 23 (15), 8804. IF: 6.2
22.tGhasemi-Gojani, E., Kovalchuk, O., Kovalchuk, I. (2022) Cannabis as a treatment for diabetes mellitus and its complications. Trends Endocrin Metabolism, 33(12), 828-849. IF: 12.0
23.tGerasymchuk, M.; Robinson, G.; Kovalchuk, O.; Kovalchuk, I. (2022) Modeling of the Senescence-Associated Phenotype in Human Skin Fibroblasts. Int. J. Mol. Sci., 23 (13), 7124. IF: 6.2
24.tSuryavanshi, SV, Zaiachuk, M, Pryimak, N, Kovalchuk, I, Kovalchuk, O. (2022) Cannabinoids alleviate the LPS-induced cytokine storm via attenuating NLRP3 inflammasome signaling and TYK2-mediated STAT3 signaling pathways in vitro. Cells, 11(9),1391. IF: 7.67
25.tFiselier A, Byeon, B, Ilnytskyy, Y, Kovalchuk, O, Kovalchuk, I. (2022) Sex-specific expression of non-coding RNA fragments in frontal cortex, hippocampus and cerebellum of rat. Epigenomes, 6(2), 11. IF: 2.5
26.tWang, B., Li, D-P, Cherkasova, V., Gerasymchuk, M., Narendran, A., Kovalchuk, I., Kovalchuk, O. (2022) Cannabinol inhibits cellular proliferation, invasion, and angiogenesis of neuroblastoma via novel miR-34a/tiMetF31/PFKFB3 axis. Cancers, 11(9), 1391. IF: 7.4
27.tKovalchuk, O., Wang, B, Li, D-P, Ilnystkyy, Y. and Kovalchuk, I. (2022) A miR-34a-guided, tRNAiMet-derived, piR_019752-like fragment (tRiMetF31) suppresses migration and angiogenesis of breast cancer cells via targeting PFKFB3. Cell Death Discovery, 8(1), 1-13. IF: 7.1
28.tKovalchuk, O., Wang, B, Li, D-P, Fiselier, A and Kovalchuk, I. (2022) New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts. Cell Death Discovery, 8(1), 1-12. IF: 7.1
29.tYadav NS, TItov, V, Ayemere, I, Byeon, B, Ilnytskyy, Y, Kovalchuk, I. (2022) Multigenerational exposure to heat stress induces phenotypic resilience, and genetic and epigenetic variations in Arabidopsis thaliana offspring. Front. Plant. Sci. 13:728167. IF: 5.75
30.tMalach, M. Kovalchuk, I. Kovalchuk, O. (2022) Medical Cannabis in Pediatric Oncology: Friend or Foe? Pharmaceuticals, 15(3), 359. IF: 5.9
2021
31.tCherkasova, V, Kovalchuk, O, Kovalchuk, I. Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer. Cancers, 13 (17), 4353. IF: 7.4
32.tZajachuk, M., Pryimak, N., Kovalchuk O., Kovalchuk, I. (2021) Cannabinoids, medical cannabis and tissue fibrosis: mechanisms and therapeutic potential. Fron. Med., 8, 713153. IF: 5.1
33.tPryimak, N. Zajachuk, M., Kovalchuk O., Kovalchuk, I. (2021) Cannabinoids, medical cannabis and tissue fibrosis: mechanisms and therapeutic potential. Fron. Cell Dev. Biol., 9, 715380. IF: 6.1
34.tBeacon, TH, Delcuve, GP, López, C, Nardocci, G, Kovalchuk, I, van Wijnen, AJ, Davie, JR. The dynamic broad epigenetic domain as a mark of essential genes. Clin. Epigen., 13 (1), 1-17, IF: 7.3.
35.tSisu, …., Kovalchuk, I…., Schuurmans, CJ. Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding. Neuron, 109 (18), 2847-2863. e11. IF: 14.4
36.tGogolev YV, … Kovalchuk I, …Yadav, NS, Viktor Korzun. OMICs, Epigenetics and Genome Editing Techniques for Food and Nutritional Security. Plants, in press. IF: 4.66
37.tSorokin, A., Yadav, N., Gaudet, D., Kovalchuk, I. (2021) Development and standardization of rapid and efficient seed germination protocol for Cannabis sativa. Bio-Protocols, 11 (1), e3875-e3875. IF: 1.0
38.tBorisov, N., Ilnytskyy, Y., Byeon, B. Kovalchuk, O. Kovalchuk, I. (2021) System, method and software for calculation of cannabis drug efficiency index in the reduction of inflammation. Int. J. Mol. Sci., 22 (1), 388. IF: 6.2
39.tBressler, K.R., Ross, J.A., Ilnytskyy, S., Vanden Dungen, K., Taylor, K., Patel, K., Zovoilis, A., Kovalchuk, I. and Nehal Thakor. (2021) Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal Kinase (JNK). Cell Stress Chaperones, 26 (1), 253-264. IF: 2.6
40.tKovalchuk, A., Wang, B., Li, D-P., Rodriguez-Juarez, R., Ilnytskyy, Y., Kovalchuk, I., Kovalchuk, O. (2021) Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19? Aging, 13, 1571-1587. IF: 5.95
Research Interests
We are interested in genetics and epigenetics of plant response to stress. We study the influence of various internal (metabolic activity, biological clock, development) and external (abiotic - ionizing and UVB radiation, chemicals; biotic - pathogens like viruses, viroids, fungi etc. stresses) factors on plant genome stability. In particular we are interested in epigenetic regulation of transgenerational adaptation to stress.
Recently, we started to work on hemp, cannabis and psychedelic mushrooms, breeding new varieties and testing their medicinal properties.
We are also interested in combinatorial treatments of various conditions associated with inflammation. We test combinations of common drugs and natural products and discover their mechanism of action and synergy.
Recently, we started to work on hemp, cannabis and psychedelic mushrooms, breeding new varieties and testing their medicinal properties.
We are also interested in combinatorial treatments of various conditions associated with inflammation. We test combinations of common drugs and natural products and discover their mechanism of action and synergy.